Science Robotics

Supplementary Materials

The PDF file includes:

  • Fig. S1. Characterization of the AuNP-decorated nanomotors.
  • Fig. S2. Motion analysis of single urease-powered nanomotors.
  • Fig. S3. In vitro imaging of urease-powered nanomotor swarms by optical microscopy.
  • Fig. S4. In vitro imaging of urease-powered nanomotor swarms by optical microscopy.
  • Fig. S5. In vitro imaging of urease-powered nanomotor swarms by optical microscopy.
  • Fig. S6. In vitro analysis of the motion of swarms of urease-powered AuNP-decorated nanomotors by optical microscopy.
  • Fig. S7. Motion analysis of the nanomotor swarms by optical microscopy.
  • Fig. S8. Analysis of large passive MSNP (without enzymes) populations.
  • Fig. S9. Motion analysis of the nanomotor swarms codropped with 5-μm PS tracer microparticles 0.01% (w/v) in water.
  • Fig. S10. Motion analysis of the nanomotor swarms codropped with 5-μm PS tracer microparticles 0.01% (w/v) in PBS.
  • Fig. S11. Fabrication of the molds for the complex paths phantoms.
  • Fig. S12. PET-CT coronal images obtained a 0.5, 7, and 25 min for each phantom, which was filled with either Milli-Q water or 300 mM urea solution.
  • Fig. S13. Analysis of the biodistribution of I-nanomotors injected intravenously.
  • Fig. S14. Image sets showing the PET images of the different bladders just after injection of nanomotors (t = 0) and 45 min later.
  • Legends for movies S1 to S9

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). Motion of single nanomotor in water and in PBS.
  • Movie S2 (.avi format). In vitro imaging of enzyme-powered nanomotor swarms in water by optical microscopy.
  • Movie S3 (.avi format). In vitro imaging of enzyme-powered nanomotor swarms in PBS by optical microscopy.
  • Movie S4 (.avi format). In vitro imaging of passive MSNPs dropped onto water and water-based urea solutions by optical microscopy.
  • Movie S5 (.avi format). In vitro imaging of enzyme-powered nanomotor swarms and tracer microparticles in water and in PBS by optical microscopy.
  • Movie S6 (.avi format). In vitro imaging of enzyme-powered nanomotor swarms by PET.
  • Movie S7 (.avi format). Effect of complex paths on the in vitro motion of 18F-radiolabeled urease-powered nanomotors studied by PET-CT imaging.
  • Movie S8 (.avi format). Study of the biodistribution of enzyme-powered nanomotors by PET-CT.
  • Movie S9 (.avi format). PET-CT analysis of the distribution of 18F-nanomotors and MSNP-18F-BSA in the bladder administered via intravesical instillation.

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