Science Robotics

Supplementary Materials

The PDF file includes:

  • Text S1. Small-animal whole-body imaging modalities and PACT
  • Fig. S1. The fabrication flow of the ingestible micromotors.
  • Fig. S2. The preparation of the MCs.
  • Fig. S3. Bright-field and fluorescence microscopic images of the micromotors confirming the successful drug loading in micromotors.
  • Fig. S4. Bright-field and fluorescence microscopic images of the MCs confirming the successful drug loading in the MCs.
  • Fig. S5. Dependence of the size of the MCs on the rotation speed of magnetic stirring.
  • Fig. S6. Long-term stability of the PA signals of the MCs under the NIR illumination used in the PACT in vitro and in vivo.
  • Fig. S7. Fluorescence imaging of the MCs in a silicone tube under tissues with different depths.
  • Fig. S8. Long-term structure stability of the MCs in the gastric fluid and the intestinal fluid.
  • Fig. S9. Velocities of Mg-based micromotors in the different media.
  • Fig. S10. Velocities of bare Mg microparticles in the different media.
  • Fig. S11. Quantification of MC migration speeds.
  • Fig. S12. Characterization of Mg dissolution in micromotors 12 hours after administration.
  • Fig. S13. Effects of cross-linking and DOX loading amount on the EE of the micromotors and dose per micromotor.
  • Fig. S14. Profile of DOX release from MCs and micromotors as a function of time.
  • Fig. S15. The weight changes of the mice after the oral administration of the MCs and the control (DI water).
  • References (5055)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). Animated illustration of the PAMR in vivo.
  • Movie S2 (.avi format). PA imaging of the migration of a MC in model intestines.
  • Movie S3 (.avi format). NIR-triggered destruction of the MC and activated autonomous propulsion of the ingestible micromotors.
  • Movie S4 (.avi format). Propulsion of the micromotors in biofluids.
  • Movie S5 (.avi format). PA imaging of the MCs in vivo for 7.5 hours.
  • Movie S6 (.avi format). PA imaging of the migration of an MC toward a model colon tumor in intestines.

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