Human adipose–derived mesenchymal stem cell–based medical microrobot system for knee cartilage regeneration in vivo

Gwangjun Go; Sin-Gu Jeong; Ami Yoo; Jiwon Han; Byungjeon Kang; Seokjae Kim; Kim Tien Nguyen; Zhen Jin; Chang-Sei Kim; Yu Ri Seo; Ju Yeon Kang; Ju Yong Na; Eun Kyoo Song; Yongyeon Jeong; Jong Keun Seon; Jong-Oh Park; Eunpyo Choi

doi:10.1126/scirobotics.aay6626

Research ArticleMEDICAL ROBOTS

Human adipose–derived mesenchymal stem cell–based medical microrobot system for knee cartilage regeneration in vivo

Gwangjun Go¹,²,*,
Sin-Gu Jeong³,*,
Ami Yoo¹,
Jiwon Han¹,
Byungjeon Kang¹,
Seokjae Kim¹,
Kim Tien Nguyen¹,²,
Zhen Jin⁴,
Chang-Sei Kim¹,²,
Yu Ri Seo⁵,
Ju Yeon Kang⁵,
Ju Yong Na⁵,
Eun Kyoo Song⁵,
Yongyeon Jeong⁶,
Jong Keun Seon⁵,†,
Jong-Oh Park¹,²,† and
Eunpyo Choi ¹,²,†

¹Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.
²School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.
³Biot Korea Inc., 43-26 Chemdangwagi-ro 208 Beon-gil, Gwangju 61001, Korea.
⁴School of Biomedical Engineering, Xinxiang Medical University, Xinxiang, Henan 453003, China.
⁵Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea.
⁶Department of Radiology, Chonnam National University Hwasun Hospital, 322 Hwasun-eup, Seoyang-ro, Hwasun 58128, Korea.

↵†Corresponding author. Email: seonbell{at}jnu.ac.kr (J.K.S.); jop{at}kimiro.re.kr (J.-O.P.); eunpyochoi{at}jnu.ac.kr (E.C.)

↵* These authors contributed equally to this work.

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Science Robotics 22 Jan 2020:
Vol. 5, Issue 38, eaay6626
DOI: 10.1126/scirobotics.aay6626

Gwangjun Go

Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.

School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.

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Sin-Gu Jeong

Biot Korea Inc., 43-26 Chemdangwagi-ro 208 Beon-gil, Gwangju 61001, Korea.

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ORCID record for Sin-Gu Jeong

Ami Yoo

Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.

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Jiwon Han

Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.

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Byungjeon Kang

Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.

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Seokjae Kim

Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.

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Kim Tien Nguyen

Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.

School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.

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Zhen Jin

School of Biomedical Engineering, Xinxiang Medical University, Xinxiang, Henan 453003, China.

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Chang-Sei Kim

Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.

School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.

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Yu Ri Seo

Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea.

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Ju Yeon Kang

Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea.

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Ju Yong Na

Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea.

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Eun Kyoo Song

Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea.

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Yongyeon Jeong

Department of Radiology, Chonnam National University Hwasun Hospital, 322 Hwasun-eup, Seoyang-ro, Hwasun 58128, Korea.

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Jong Keun Seon

Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea.

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For correspondence: seonbell@jnu.ac.kr jop@kimiro.re.kr eunpyochoi@jnu.ac.kr

Jong-Oh Park

Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.

School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.

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For correspondence: seonbell@jnu.ac.kr jop@kimiro.re.kr eunpyochoi@jnu.ac.kr

Eunpyo Choi

Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.

School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Korea.

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For correspondence: seonbell@jnu.ac.kr jop@kimiro.re.kr eunpyochoi@jnu.ac.kr

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Human adipose–derived mesenchymal stem cell–based medical microrobot system for knee cartilage regeneration in vivo

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