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Research ArticleMEDICAL ROBOTS
An actuatable soft reservoir modulates host foreign body response
- View ORCID ProfileE. B. Dolan1,2,3,
- View ORCID ProfileC. E. Varela1,4,
- K. Mendez1,4,
- View ORCID ProfileW. Whyte1,5,6,7,
- R. E. Levey3,
- View ORCID ProfileS. T. Robinson3,6,7,
- View ORCID ProfileE. Maye3,
- J. O’Dwyer2,3,
- R. Beatty3,
- View ORCID ProfileA. Rothman8,
- View ORCID ProfileY. Fan8,
- J. Hochstein4,
- S. E. Rothenbucher1,
- View ORCID ProfileR. Wylie3,
- View ORCID ProfileJ. R. Starr9,
- View ORCID ProfileM. Monaghan5,10,
- View ORCID ProfileP. Dockery3,11,
- View ORCID ProfileG. P. Duffy3,5,6,7,11,*,† and
- View ORCID ProfileE. T. Roche1,8,*,†
- 1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
- 2Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.
- 3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
- 4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.
- 5Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
- 6Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
- 7Royal College of Surgeons in Ireland, Dublin, Ireland.
- 8Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
- 9Epidemiology and Biostatistics Core, The Forsyth Institute, 245 First Street, Cambridge, MA, USA.
- 10Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.
- 11CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
- ↵†Corresponding author. Email: garry.duffy{at}nuigalway.ie (G.P.D.); etr{at}mit.edu (E.T.R.)
↵* These authors jointly supervised this work.
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Science Robotics 28 Aug 2019:
Vol. 4, Issue 33, eaax7043
DOI: 10.1126/scirobotics.aax7043
Vol. 4, Issue 33, eaax7043
DOI: 10.1126/scirobotics.aax7043
E. B. Dolan
1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
2Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.
3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
C. E. Varela
1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.
K. Mendez
1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.
W. Whyte
1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
5Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
6Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
7Royal College of Surgeons in Ireland, Dublin, Ireland.
R. E. Levey
3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
S. T. Robinson
3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
6Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
7Royal College of Surgeons in Ireland, Dublin, Ireland.
E. Maye
3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
J. O’Dwyer
2Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.
3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
R. Beatty
3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
A. Rothman
8Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Y. Fan
8Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
J. Hochstein
4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.
S. E. Rothenbucher
1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
R. Wylie
3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
J. R. Starr
9Epidemiology and Biostatistics Core, The Forsyth Institute, 245 First Street, Cambridge, MA, USA.
M. Monaghan
5Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
11CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
P. Dockery
3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
11CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
G. P. Duffy
3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
5Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
6Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
7Royal College of Surgeons in Ireland, Dublin, Ireland.
11CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
E. T. Roche
1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
8Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
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