An actuatable soft reservoir modulates host foreign body response

E. B. Dolan; C. E. Varela; K. Mendez; W. Whyte; R. E. Levey; S. T. Robinson; E. Maye; J. O’Dwyer; R. Beatty; A. Rothman; Y. Fan; J. Hochstein; S. E. Rothenbucher; R. Wylie; J. R. Starr; M. Monaghan; P. Dockery; G. P. Duffy; E. T. Roche

doi:10.1126/scirobotics.aax7043

Research ArticleMEDICAL ROBOTS

An actuatable soft reservoir modulates host foreign body response

View ORCID ProfileE. B. Dolan ¹,²,³,
View ORCID ProfileC. E. Varela ¹,⁴,
K. Mendez¹,⁴,
View ORCID ProfileW. Whyte¹,⁵,⁶,⁷,
R. E. Levey³,
View ORCID ProfileS. T. Robinson ³,⁶,⁷,
View ORCID ProfileE. Maye³,
J. O’Dwyer²,³,
R. Beatty³,
View ORCID ProfileA. Rothman⁸,
View ORCID ProfileY. Fan⁸,
J. Hochstein⁴,
S. E. Rothenbucher¹,
View ORCID ProfileR. Wylie³,
View ORCID ProfileJ. R. Starr⁹,
View ORCID ProfileM. Monaghan⁵,¹⁰,
View ORCID ProfileP. Dockery³,¹¹,
View ORCID ProfileG. P. Duffy ³,⁵,⁶,⁷,¹¹,*,† and
View ORCID ProfileE. T. Roche ¹,⁸,*,†

¹Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
²Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.
³Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
⁴Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.
⁵Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
⁶Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
⁷Royal College of Surgeons in Ireland, Dublin, Ireland.
⁸Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁹Epidemiology and Biostatistics Core, The Forsyth Institute, 245 First Street, Cambridge, MA, USA.
¹⁰Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.
¹¹CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.

↵†Corresponding author. Email: garry.duffy{at}nuigalway.ie (G.P.D.); etr{at}mit.edu (E.T.R.)

↵* These authors jointly supervised this work.

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Science Robotics 28 Aug 2019:
Vol. 4, Issue 33, eaax7043
DOI: 10.1126/scirobotics.aax7043

E. B. Dolan

1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

2Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.

3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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C. E. Varela

1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

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K. Mendez

1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

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W. Whyte

1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

5Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

6Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.

7Royal College of Surgeons in Ireland, Dublin, Ireland.

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R. E. Levey

3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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S. T. Robinson

3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

6Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.

7Royal College of Surgeons in Ireland, Dublin, Ireland.

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E. Maye

3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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J. O’Dwyer

2Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.

3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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R. Beatty

3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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A. Rothman

8Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Y. Fan

8Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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J. Hochstein

4Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

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S. E. Rothenbucher

1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

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R. Wylie

3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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J. R. Starr

9Epidemiology and Biostatistics Core, The Forsyth Institute, 245 First Street, Cambridge, MA, USA.

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M. Monaghan

5Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

11CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.

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P. Dockery

3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

11CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.

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G. P. Duffy

3Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

5Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

6Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.

7Royal College of Surgeons in Ireland, Dublin, Ireland.

11CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.

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For correspondence: garry.duffy@nuigalway.ie etr@mit.edu

E. T. Roche

1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

8Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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For correspondence: garry.duffy@nuigalway.ie etr@mit.edu

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