An actuatable soft reservoir modulates host foreign body response

E. B. Dolan; C. E. Varela; K. Mendez; W. Whyte; R. E. Levey; S. T. Robinson; E. Maye; J. O’Dwyer; R. Beatty; A. Rothman; Y. Fan; J. Hochstein; S. E. Rothenbucher; R. Wylie; J. R. Starr; M. Monaghan; P. Dockery; G. P. Duffy; E. T. Roche

doi:10.1126/scirobotics.aax7043

Research ArticleMEDICAL ROBOTS

An actuatable soft reservoir modulates host foreign body response

E. B. Dolan ¹,²,³,
C. E. Varela ¹,⁴,
K. Mendez¹,⁴,
W. Whyte¹,⁵,⁶,⁷,
R. E. Levey³,
S. T. Robinson ³,⁶,⁷,
E. Maye³,
J. O’Dwyer²,³,
R. Beatty³,
A. Rothman⁸,
Y. Fan⁸,
J. Hochstein⁴,
S. E. Rothenbucher¹,
R. Wylie³,
J. R. Starr⁹,
M. Monaghan⁵,¹⁰,
P. Dockery³,¹¹,
G. P. Duffy ³,⁵,⁶,⁷,¹¹,*,† and
E. T. Roche ¹,⁸,*,†

¹Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
²Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.
³Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
⁴Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.
⁵Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
⁶Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.
⁷Royal College of Surgeons in Ireland, Dublin, Ireland.
⁸Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁹Epidemiology and Biostatistics Core, The Forsyth Institute, 245 First Street, Cambridge, MA, USA.
¹⁰Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.
¹¹CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.

↵†Corresponding author. Email: garry.duffy{at}nuigalway.ie (G.P.D.); etr{at}mit.edu (E.T.R.)

↵* These authors jointly supervised this work.

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Science Robotics 28 Aug 2019:
Vol. 4, Issue 33, eaax7043
DOI: 10.1126/scirobotics.aax7043

E. B. Dolan

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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C. E. Varela

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

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K. Mendez

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

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W. Whyte

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.Royal College of Surgeons in Ireland, Dublin, Ireland.

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R. E. Levey

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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S. T. Robinson

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.Royal College of Surgeons in Ireland, Dublin, Ireland.

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E. Maye

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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J. O’Dwyer

Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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R. Beatty

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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A. Rothman

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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Y. Fan

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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J. Hochstein

Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

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S. E. Rothenbucher

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

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R. Wylie

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

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J. R. Starr

Epidemiology and Biostatistics Core, The Forsyth Institute, 245 First Street, Cambridge, MA, USA.

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M. Monaghan

Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.

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P. Dockery

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G. P. Duffy

Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.Royal College of Surgeons in Ireland, Dublin, Ireland.CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.

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For correspondence: garry.duffy@nuigalway.ie etr@mit.edu

E. T. Roche

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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For correspondence: garry.duffy@nuigalway.ie etr@mit.edu

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